What is Spermatogenesis?
Spermatogenesis is the process by which the male body makes sperm cells.
It happens in the testes, inside tiny coiled tubes called seminiferous tubules.
It starts during puberty and continues for a man’s entire life.
The goal is to make sperm that can fertilise a female egg.
Where Does It Happen?
• In the testes of males
• Inside tiny tubes called seminiferous tubules
• The process is controlled by hormones and begins at puberty
The Full Process of How Sperm Is Made (Spermatogenesis)
Step 1: Spermatogonia (Starter Cells)
• These are stem cells at the edge of the seminiferous tubules.
• They have 46 chromosomes (diploid).
• Some stay as stem cells to keep the process going.
• Others divide by mitosis to make primary spermatocytes.
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Step 2: Primary Spermatocyte
• Each one is diploid (46 chromosomes).
• It prepares for meiosis, which is a special type of cell division to reduce chromosome number.
• It goes through meiosis I, where the chromosomes are mixed and split.
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Step 3: Secondary Spermatocytes
• After meiosis I, the primary spermatocyte becomes two secondary spermatocytes.
• These cells now have 23 chromosomes (haploid).
• They are halfway to becoming sperm.
• They go through meiosis II, a second division.
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Step 4: Spermatids
• Each secondary spermatocyte forms two spermatids (total of 4 from one primary spermatocyte).
• Spermatids are round, immature, and can’t swim yet.
• They still have 23 chromosomes.
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Step 5: Spermiogenesis – Maturing into Sperm
• Spermatids now change shape:
• They grow a tail (flagellum) for swimming
• The nucleus becomes smaller and more compact (to carry DNA)
• They lose extra parts they don’t need
• This transformation makes them into spermatozoa (mature sperm).
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Final Product: Spermatozoa (Sperm Cells)
• These are long, streamlined cells with:
• A head (with DNA and enzymes to enter the egg)
• A midpiece (with mitochondria for energy)
• A tail (to swim toward the egg)
• Each sperm has 23 chromosomes — half of the father’s genetic information.
Favourite part/ note/ summary— Spermatogenesis is the process where sperm is made. There are 5 stages Spermatogonia, Primary Spermatocyte, Secondary Spermatocytes, Spermatids.
Spermatogonia is the starter cell, starts in testes inside tiny tubes called seminiferous tubules. Spermatogonia (starter cells) divide to form primary spermatocytes. Primary spermatocytes split into secondary spermatocytes (meiosis I).
Secondary spermatocytes split again into spermatids (meiosis II). Spermatids grow tails and change shape to become sperm (spermatozoa). Each sperm has 23 chromosomes and can fertilize an egg.
How to Approach This Topic:
As a student who wants to research this more deeply, you should build on this great foundation. Here is how you can do that:
Study the Hormones: This process doesn't happen on its own. Research the hormones that control it, like FSH (Follicle-Stimulating Hormone), LH (Luteinizing Hormone), and Testosterone. Find out what each hormone does.
Learn About the Helper Cells: Sperm cells need help to develop. Learn about Sertoli cells (which protect and feed the developing sperm) and Leydig cells (which make testosterone).
Compare it to Oogenesis: Look up "oogenesis," which is the process of making eggs in females. Compare the two processes. Notice the differences in timing and the number of cells they produce.
Think About What Can Go Wrong: Research what happens if spermatogenesis doesn't work correctly. This can lead you to understand topics like infertility and the effects of lifestyle on sperm production.
Questions to Make You Think Deeper:
Here are three questions to help you explore this topic in more detail:
A man produces millions of sperm every day, but a woman releases only one egg per month. Why do you think there is such a big difference in the number of sperm and eggs produced?
The process of making sperm (spermatogenesis) involves two special cell divisions (meiosis I and II) to cut the number of chromosomes in half. What problems could arise in a baby if one of these divisions goes wrong and a sperm ends up with the wrong number of chromosomes?
Spermatogenesis starts during puberty and can continue for a man's entire life. What signals in the body tell the testes to start this process at puberty, and how does the body keep it going for so many decades?